NeuroMat renewed for a six-year term

The Research, Innovation and Dissemination Center for Neuromathematics (RIDC NeuroMat), created by the São Paulo Research Foundation (FAPESP) in 2013, has been renewed until July 31, 2024. The renewal has been approved by FAPESP on November 12, based on a general positive evaluation by the International Assessment Committee in 2017 and the fulfillment of further requests by FAPESP.

Parkinson's disease: singing reduces stress and improves motor functions

This month on G1 website, a Brazilian news portal maintained by the Globo Group, there was a report on people with Parkinson's Disease, this time stating that singing can decrease stress and improve their motor functions. G1 website report highlights that in Brazil, the Amparo Network - a NeuroMat initiative - is one of the entities that brings together patients, family members, caregivers and health professionals to improve the quality of life of people living with the Parkinson's Disease. Portal G1, 15/11/2018. (In Portuguese.)

Plasticity in the Brain after a Traumatic Brachial Plexus Injury in Adults

Claudia Vargas, Fernanda Torres, Bia Ramalho, Cristiane Patroclo, Lidiane Souza, Fernanda Guimarães, José Vicente Martins and Maria Luíza Rangel

In this chapter, we aim to discuss the neurophysiological basis of the brain reorganization (also called plasticity) that associates with a traumatic brachial plexus injury (TBPI), as well as following the brachial plexus surgical reconstruction and its physical rehabilitation. We start by reviewing core aspects of plasticity following peripheral injuries such as amputation and TBPI as well as those associated with chronic pain conditions. Then, we present recent results collected by our team centered on physiological measurements of plasticity after TBPI. Finally, we discuss that an important limitation in the field is the lack of systematic measurement of TBPI clinical features. We finish by proposing possible future venues in the domain of brain plasticity following a TBPI.

Firing properties of ventral medullary respiratory neurons in sino-aortic denervated rats

Amorim MR, Pena RFO, Souza GMPR, Bonagamba LGH, Roque AC and Machado BH

In previous studies we documented that after sino-aortic denervation (SAD) in rats there are significant changes in the breathing pattern, but no significant changes in sympathetic activity and mean arterial pressure (MAP) compared with Sham-operated rats. However, the neural mechanisms involved in the respiratory changes after SAD and the extent to which they may contribute to the observed normal sympathetic activity and MAP remain unclear. Here, we hypothesized that after SAD, rats present with changes in the firing frequency of the ventral medullary inspiratory and post-inspiratory neurons. To test this hypothesis, male Wistar rats underwent SAD or Sham surgery and 3 days later were surgically prepared for an in situ preparation. The duration of inspiration significantly increased in SAD rats. During inspiration, the total firing frequency of Ramp-I, Pre-I / I, and Late-I neurons was not different between groups. During post-inspiration, the total firing frequency of Post-I neurons was also not different between groups. Furthermore, the data demonstrate a reduced interburst frequency of Pre-I/I and an increased long-term variability of Late-I neurons in SAD compared with Sham rats. These findings indicate that the SAD-induced prolonged inspiration was not accompanied by alterations in the total firing frequency of the ventral medullary respiratory neurons, but it was associated with changes in the long-term variability of Late-I neurons. We suggest that the timing imbalance in the respiratory network in SAD rats may contribute to the modulation of presympathetic neurons after removal of baroreceptor afferents.

Openings for Software Developers

The Research, Innovation and Dissemination Center on Neuromathematics (RIDC NeuroMat) is offering scholarships for information technology professionals interested in being part of a breakthrough and innovative scientific project.




The Research, Innovation and Dissemination Center for Neuromathematics is hosted by the University of São Paulo and funded by FAPESP (São Paulo Research Foundation).


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