Investigation of rat exploratory behavior via evolving artificial neural networks

Ariadne de Andrade Costa and Renato Tinós

Background: Neuroevolution comprises the use of evolutionary computation to define the architecture and/or to train artificial neural networks (ANNs). This strategy has been employed to investigate the behavior of rats in the elevated plus-maze, which is a widely used tool for studying anxiety in mice and rats. New method: Here we propose a neuroevolutionary model, in which both the weights and the architecture of artificial neural networks (our virtual rats) are evolved by a genetic algorithm. Comparison with Existing Methods: This model is an improvement of a previous model that involves the evolution of just the weights of the ANN by the genetic algorithm. In order to compare both models, we analyzed traditional measures of anxiety behavior, like the time spent and the number of entries in both open and closed arms of the maze. Results: When compared to real rat data, our findings suggest that the results from the model introduced here are statistically better than those from other models in the literature. Conclusions: In this way, the neuroevolution of architecture is clearly important for the development of the virtual rats. Moreover, this technique allowed the comprehension of the importance of different sensory units and different number of hidden neurons (performing as memory) in the ANNs (virtual rats).

LASCON: a video presentation

A NeuroMat initiative, the Latin American School on Computational Neuroscience (LASCON) is one of the most important computational neuroscience schools in the world. Its mission is to provide an intensive training for advanced undergraduate and graduate students, an introduction to mathematical and computational tools for neural modeling and analysis. The school relies on theory-driven sections and practical, hands-on activities.

A NeuroMat project group to simulate cortical networks using stochastic models

During the last NeuroMat workshop, PI Antonio Carlos Roque presented a project on simulating neuronal behaviors associated to the Galves-Löcherbach model. Computational simulation could provide insights on brain dynamics, especially with working with very large sample sizes.

Streaming of the Second NeuroMat Workshop, New Frontiers in NeuroMathematics

Seven videos of the Second NeuroMat Workshop, New Frontiers in NeuroMathematics, that occurred from November 22 to 25, at the University of São Paulo. Streaming was made available by USP. Videos in English.

A brain soccer derby

An interesting way of thinking on brain functioning --and research in this area-- is to compare neurons to soccer fans in a stadium. Scientists would be observers "outside" the stadium, trying to make sense of what goes on "on the field." Antonio Galves, Mente e Cérebro, 01/2017. (In Portuguese.)




O Centro de Pesquisa, Inovação e Difusão em Neuromatemática está sediado na Universidade de São Paulo e é financiado pela FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo).


Login do usuário



Rua do Matão, 1010 - Cidade Universitária - São Paulo - SP - Brasil. 05508-090. Veja o mapa.

55 11 3091-1717


Contatos de mídia: