Graph analysis of verbal fluency test discriminate between patients with Alzheimer's disease, mild cognitive impairment and normal elderly controls

Laiss Bertola, Natália B. Mota, Mauro Copelli, Thiago Rivero, Breno Satler Diniz, Marco A. Romano-Silva, Sidarta Ribeiro, and Leandro F. Malloy-Diniz

Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the elderly, and different analytical methods are likely to extract even more information from the data generated in this test. Graph theory, a mathematical approach to analyze relations between items, represents a promising tool to understand a variety of neuropsychological states. This study reports a graph analysis of data generated by the semantic verbal fluency test by cognitively healthy elderly (NC), patients with Mild Cognitive Impairment—subtypes amnestic (aMCI) and amnestic multiple domain (a+mdMCI)—and patients with Alzheimer's disease (AD).

A model for neural activity in the absence of external stimuli

Aline Duarte, Guilherme Ost

We study a stochastic process describing the continuous time evolution of the membrane potentials of finite system of neurons in the absence of external stimuli. The values of the membrane potentials evolve under the effect of chemical synapses, electrical synapses and a leak current.

Prof. Sidarta Ribeiro spreads neuroscience

NeuroMat member Prof. Sidarta Ribeiro took part on November, 13, of a diffusion activity on neuroscience in a school in Cotia, São Paulo State. Report and image by William Melo, Revista Circuito, 11/14/2014.


NeuroMat offers training on spike sorting

The cooperation between neuroscience and mathematics has much to offer to the collection of neural data. The Research, Innovation and Dissemination Center for Neuromathematics (CEPID NeuroMat), from the University of São Paulo, offers a training on the mathematical challenges of this area, specifically on advances developed on techniques of spike sorting.Report by Revista Mente e Cérebro, 11/2014.

The onset of data-driven mental archeology

Sidarta Ribeiro

How did human consciousness arise, in comparison with that of apes? This question has motivated many hypotheses, from psychoanalysis (Freud, 1939) and literature (Bloom, 1999) to evolutionary psychology (Dennett, 1997; Tomasello, 2014). One of the most provocative is that of Julian Jaynes (1976), who understood the question as pertaining to the cultural evolution of introspection during the first millennium BC, known as Axial Age (Jaspers, 1953).

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The Research, Innovation and Dissemination Center for Neuromathematics is hosted by the University of São Paulo and funded by FAPESP (São Paulo Research Foundation).

 

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