Self-sustained activity of low firing rate in balanced networks

Fernando Borges, Paulo Protachevicz, Rodrigo Pena, Ewandson Lameu, Guilherme Higa, Fernanda Matias, Alexandre Kihara, Chris Antonopoulos, Roberto de Pasquale, Antonio Roque, Kelly Iarosz, Peng Ji and Antonio Batista

Self-sustained activity in the brain is observed in the absence of external stimuli and contributes to signal propagation, neural coding, and dynamic stability. It also plays an important role in cognitive processes. In this work, by means of studying intracellular recordings from CA1 neurons in rats and results from numerical simulations, we demonstrate that self-sustained activity presents high variability of patterns, such as low neural firing rates and activity in the form of small-bursts in distinct neurons. In our numerical simulations, we consider random networks composed of coupled, adaptive exponential integrate-and-fire neurons. The neural dynamics in the random networks simulates regular spiking (excitatory) and fast spiking (inhibitory) neurons. We show that both the connection probability and network size are fundamental properties that give rise to self-sustained activity in qualitative agreement with our experimental results. Finally, we provide a more detailed description of self-sustained activity in terms of lifetime distributions, synaptic conductances, and synaptic currents.

The whole paper is available here.

NeuroCineMat
Featuring this week:
Newsletter

Stay informed on our latest news!



Previous issues

Podcast A Matemática do Cérebro
Podcast A Matemática do Cérebro
NeuroMat Brachial Plexus Injury Initiative
Logo of the NeuroMat Brachial Plexus Injury Initiative
Neuroscience Experiments System
Logo of the Neuroscience Experiments System
NeuroMat Parkinson Network
Logo of the NeuroMat Parkinson Network
NeuroMat's scientific-dissemination blog
Logo of the NeuroMat's scientific-dissemination blog