The NeuroMat scientific dissemination has released a video that presents the work of research Fernando Najman in the NeuroMat research team. This video was produced with an immersive technique, so it is possible to wander around as Najman presents on various aspects of his work.
The Neuroscience Experiments System (NES) is a by-product of the technology-transfer team of FAPESP's Research, Innovation and Dissemination Center for Neuromathematics. An open-source tool, it is used to manage clinical data gathered in hospitals and research institutions. It is also a relevant resource for reproducible science.
Ceballos C. C., Roque A. C. and Leão R. M.
Neuronal subthreshold voltage-dependent currents determine membrane properties such as the input resistance (Rin) and the membrane time constant (τm) in the subthreshold range. In contrast with classical cable theory predictions, the persistent sodium current (INaP), a non-inactivating mode of the voltage-dependent sodium current, paradoxically increases Rin and τm when activated. Furthermore, this current amplifies and prolongs synaptic currents in the subthreshold range. Here, using a computational neuronal model, we showed that the creation of a region of negative slope conductance by INaP activation is responsible for these effects and the ability of the negative slope conductance to amplify and prolong Rin and τm relies on the fast activation of INaP. Using dynamic clamp in hippocampal CA1 pyramidal neurons in brain slices, we showed that the effects of INaP on Rin and τm can be recovered by applying an artificial INaP after blocking endogenous INaP with tetrodotoxin. Furthermore, we showed that injection of a pure negative conductance is enough to reproduce the effects of INaP on Rin and τm and is also able to prolong artificial excitatory post synaptic currents. Since both the negative slope conductance and the almost instantaneous activation are critical for producing these effects, the INaP is an ideal current for boosting the amplitude and duration of excitatory post synaptic currents near the action potential threshold.
The whole paper is available here.
Natália B. Mota, Renata Callipo, Lígia Leite, Ana R. Torres, Janaína Weissheimer, Silvia A. Bunge, Mauro Copelli and Sidarta Ribeiro
Formal thought organization obtained from free speech, a key feature for psychiatric evaluations, has been poorly investigated during typical development. Computational tools such as speech graph connectedness (LSC) currently allow for an accurate quantification in naturalistic settings. LSC's typical development is better predicted by years of education than by age. Among beginning readers, the LSC of stories composed of short‐term memory predicted reading independently from IQ. Here we set out to test a longitudinal sample (6–8 years old, n = 45, followed for 2 years) to verify whether the LSC is predictive of various memory measures, and whether such relations can explain the correlation with reading. The LSC was specifically correlated with verbal short‐term memory performance. The results support the notion that the short‐term storage of verbal information is necessary to plan a story. Given the limited sample size, the relationship of this interaction with reading remains inconclusive.
The whole paper is available here.
The Research, Innovation and Dissemination Center for Neuromathematics (NeuroMat), hosted by the University of São Paulo, Brazil, and funded by the São Paulo Research Foundation (FAPESP), is offering two post-doctoral fellowships for recent PhDs with outstanding research potential. The research will involve collaborations with experimental and theoretical groups and laboratories associated to NeuroMat.
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